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M9490025.TXT
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1994-09-03
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Document 0025
DOCN M9490025
TI Carbon monoxide-diffusing capacity in intravenous drug abusers: the
effect of cigarette smoking and HIV infection.
DT 9411
AU Foresti V; Villa A; De Filippi G; Numeroso R; III Divisione di Medicina
Generale, Ospedale Fatebenefratelli,; Milano.
SO Recenti Prog Med. 1994 Jun;85(6):323-7. Unique Identifier : AIDSLINE
MED/94323527
AB A reduction in the Dco has been frequently found in intravenous drug
addicts (IVDAs) and in subjects with HIV infection. Since also cigarette
smoking decreases Dco, we studied a group of street IVDAs, who did not
show respiratory symptoms and/or infiltrates on chest x-ray film.
Sixty-two patients were presently smoking, 2 had never smoked.
Twenty-seven were HIV-negative and 37 HIV-positive. Mean values for Dco
(percent of predicted values) were 78 +/- 16.4 in HIV-positives compared
to 97.9 +/- 17.6 in HIV-negatives (p < 0.0001) using smoking specific
equations and 71.8 +/- 15.4 in HIV-positives compared to 80.7 +/- 13.4
(p < 0.0001) using non-smokers equations. Dco was < 80 percent in 19 of
35 (54.3%) HIV-positive subjects and in 4 of 26 (15.4%) HIV-negative
subjects (p < 0.009) using predicted values for smokers, and in 28 of 35
(80%) HIV-positive subjects and in 6 of 26 (23.1%) HIV-negative subjects
(p < 0.0001) using predicted values for non-smokers. These data suggest
that Dco alterations observed in HIV-positive subjects are due, in
absence of respiratory symptoms and/or chest x-ray abnormalities, to an
interstitial pneumopathy due to HIV or to a subclinical pulmonary
disease. We conclude that the knowing of smoking in IVDAs is useful, but
the knowing of seropositivity is much more important, since a marked
reduction of Dco in these subjects suggests an HIV-related lymphocytic
alveolitis, an opportunistic infection or a malignancy.
DE Adolescence Adult *Carbon Monoxide Comparative Study Female Human
HIV Infections/*PHYSIOPATHOLOGY HIV Seronegativity/PHYSIOLOGY HIV
Seropositivity/PHYSIOPATHOLOGY *HIV-1/IMMUNOLOGY Male *Narcotics
Prospective Studies *Pulmonary Diffusing Capacity
Smoking/*PHYSIOPATHOLOGY *Street Drugs Substance Abuse,
Intravenous/*PHYSIOPATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).